Thursday, March 28
- Orioles vs. Angels (Corbin Burnes vs. Patrick Sandoval), 3:05 p.m. ET
- Reds vs. Nationals (Frankie Montas vs. Josiah Gray), 4:10 p.m. ET
- Padres vs. Giants (Yu Darvish vs. Logan Webb), 4:10 p.m. ET
- Dodgers vs. Cardinals (Tyler Glasnow vs. Miles Mikolas), 4:10 p.m. ET
- Rays vs. Blue Jays (Zach Eflin vs. José Berríos), 4:10 p.m. ET
- Marlins vs. Pirates (Jesús Luzardo vs. Mitch Keller), 4:10 p.m. ET
- Royals vs. Twins (Cole Ragans vs. Pablo López), 4:10 p.m. ET
- Astros vs. Yankees (Framber Valdez vs. Nestor Cortes), 4:10 p.m. ET
- White Sox vs. Tigers (Garrett Crochet vs. Tarik Skubal), 4:10 p.m. ET
- Rangers vs. Cubs (Nathan Eovaldi vs. Justin Steele), 7:35 p.m. ET
- Athletics vs. Guardians (Alex Wood vs. Shane Bieber), 10:07 p.m. ET
- Diamondbacks vs. Rockies (Zac Gallen vs. Kyle Freeland), 10:10 p.m. ET
- Mariners vs. Red Sox (Luis Castillo vs. Brayan Bello), 10:10 p.m. ET
Friday, March 29 (openers rescheduled due to rain)
- Mets vs. Brewers (Jose Quintana vs. Freddy Peralta), 1:40 p.m. ET
- Phillies vs. Braves (Zack Wheeler vs. Spencer Strider), 3:05 p.m. ET
